There literally isn’t too much to say about this right now but Fallout 4 will be VR compatible next year.
Bethesda is bringing Fallout 4 to the HTC Vive and there was no mention of the Oculus Rift at all. It’s not surprising there was no mention of the Oculus Rift because back in 2014 Zenimax filed a legal suit against Oculus for “illegally misappropriating ZeniMax trade secrets relating to virtual reality technology, and infringing ZeniMax copyrights and trademarks.”
How it will work with the Vive is unknown, but we assume they have come up with a way to play it without making players motion sick. First-person games aren’t great as a seated experience, and standing up and moving in-game without moving your legs can also give some strange reactions.
You can, of course, play the game in VR right now with third-party tools such as VorpX.